| Parathyroid carcinoma | |
|---|---|
| Classification and external resources | |
| ICD-10 | C75.0 |
| ICD-9 | 194.1 |
| DiseasesDB | 9628 |
| eMedicine | med/1754 |
| MeSH | D010282 |
Parathyroid carcinoma is a rare cause of hypercalcemia.[1] It forms in tissues of one or more of the parathyroid glands (four pea-sized glands in the neck that make parathyroid hormone, which helps the body store and use calcium).
It is rare,[2] and much less common than parathyroid adenoma.
It can be difficult to excise.[3]
Contents |
Parathyroid cancer occurs in midlife at the same rate in men and women.
Conditions that appear to result in an increased risk of parathyroid cancer include multiple endocrine neoplasia type 1,[4] autosomal dominant familial isolated hyperparathyroidism[4] and hyperparathyroidism-jaw tumor syndrome[1] (which also is hereditary)[1]. Parathyroid cancer has also been associated with external radiation exposure, but, most reports describe an association between radiation and the more common parathyroid adenoma.[4]
Most patients experience moderate to severe hypercalcemia and high parathyroid hormone levels. A large mass in the neck is often seen, and renal and bone abnormalities are common.[1]
Parathyroid carcinoma is sometimes diagnosed during surgery for primary hyperparathyroidism. If the surgeon suspects carcinoma based on severity or invasion of surrounding tissues by a firm parathyroid tumor, aggressive excision is performed, including the thyroid and surrounding tissues as necessary.[1]
now agents like calcimimetics are used to lower the calcium level in body to lower the effects of high calcium in blood.
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".
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